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KMID : 0881720100250030209
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Journal of Food Hygiene and Safety
2010 Volume.25 No. 3 p.209 ~ p.214
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Brazilin Inhibits of TPA-induced MMP-9 Expression Via the Suppression of NF-κB Activation in MCF-7 Human Breast Carcinoma Cells
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Kim Byeong-Soo
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Abstract
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Metastasis is the primary cause of from breast cancer mortality. Cell migration and invasion play important roles in neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in cancer cell invasion. NF-κB is transcription factor important in the regulation of MMP-9, as the promoter of MMP-9 gene contains binding sites for NF-κB. Brazilin, an active component of sappan wood (Caesalpinia sappan), decreases TPA-induced MMP-9 expression and invasion in MCF-7 cells. Also, brazilin suppressed NF-κB activation in TPA-treated MCF-7 cells. Taken together, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by brazilin is mediated by the suppression of the NF-κB pathway in MCF-7 cells. This result suggest brazilin provide a potential therapeutic approach for the treatment of breast cancer.
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KEYWORD
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Brazilin, MMP-9, metastasis, invasion, NF-κB, MCF-7
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